First Asymmetric Synthesis of a 6-Alkoxy-5,6-dihydro-1,3-oxazine: A Promising Enantioselective Route to β-Amido Aldehydes
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https://figshare.com/articles/dataset/First_Asymmetric_Synthesis_of_a_6-Alkoxy-5_6-dihydro-1_3-oxazine_A_Promising_Enantioselective_Route_to_-Amido_Aldehydes/3761631
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资源简介：
The 1,3-oxazine route to enantiopure β-amido aldehydes was investigated. Heterocycloaddition of the N-acyl imine 1 with (R)-O-vinylpantolactone
provided the stable dihydroxazine 4c. High diastereocontrols were observed when using Yb(fod)3-catalyzed or SnCl4-mediated conditions,
thus leading after quantitative hydrolysis to (R)-N-benzoyl-3-phenylpropanal with >98% ee.
创建时间：
2016-08-26
