Crystal structure of monkeypox virus methyltransferase VP39 in complex with inhibitor TO494

Crystal structure of monkeypox virus methyltransferase VP39 in complex with inhibitor TO494 Descriptor: (2~{S})-2-azanyl-4-[[(2~{S},3~{S},4~{R},5~{R})-5-[4-azanyl-5-(2-naphthalen-1-ylethynyl)pyrrolo[2,3-d]pyrimidin-7-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methylsulfanyl]butanoic acid, Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase Authors: Klima, M, Silhan, J, Boura, E. Deposit date: 2023-02-02 Release date: 2023-04-05 Last modified: 2024-06-19 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Discovery and structural characterization of monkeypox virus methyltransferase VP39 inhibitors reveal similarities to SARS-CoV-2 nsp14 methyltransferase. Nat Commun, 14, 2023