Crystal structure of DDB1-CRBN-BRD4(BD1) complex bound to dBET6 PROTAC.
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Crystal structure of DDB1-CRBN-BRD4(BD1) complex bound to dBET6 PROTAC. Descriptor: 2-[(6S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl]-N-(8-{[({2-[(3S)-2,6-dioxopiperidin-3-yl]-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl}oxy)acetyl]amino}octyl)acetamide, Bromodomain-containing protein 4, DNA damage-binding protein 1, ... Authors: Nowak, R.P, DeAngelo, S.L, Buckley, D, Bradner, J.E, Fischer, E.S. Deposit date: 2017-11-21 Release date: 2018-05-30 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (3.33 Å) Cite: Plasticity in binding confers selectivity in ligand-induced protein degradation. Nat. Chem. Biol., 14, 2018
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2017-11-21
