Supplementary Material for: Polycystic Ovary Syndrome, Endometriosis and Venous Thromboembolism: A population-based study

Background: There is a paucity of studies on the association between polycystic ovary syndrome (PCOS) and endometriosis and the occurrence of venous thromboembolism (VTE).
Objective: Our study aimed to evaluate the association between PCOS, endometriosis, deep vein thrombosis (DVT) and pulmonary embolism (PE).
Methods: This was a retrospective study of prospectively collected data using the Healthcare Cost and Utilization Project database. We examined the association between PCOS and endometriosis with DVT and PE from a cohort of 12,814,970 female patients, aged 18 to 49 years, who were hospitalized between 2007 and 2014.
Results: We observed increasing trends, with a relative increase of 140% (from 0.27% to 0.65%) for PCOS, 16% (from 0.43% to 0.50%) for DVT, and 39% (from 0.23% to 0.32%) for PE, whereas we observed a decline by 34% for endometriosis (from 0.85% to 0.56%). The unadjusted analysis showed an association between PCOS and VTE, which remained significant after adjustment for sociodemographic characteristics and comorbidities (OR=2.16; 95%CI 2.00-2.33 and 2.44; 95%CI 2.23-2.67 for DVT and PE, respectively). The association between endometriosis and VTE was age-dependent, with an increased risk of VTE among women 18-24 years whereas this risk was decreased among those 35 years and older.
Conclusion: Our study indicates an association between PCOS and VTE, and an age-dependent association between endometriosis and VTE.