Doxorubicin Changes the Spatial Organization of the Genome around Active Promoters
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE215318
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To investigate the function of the TOP2 inhibitors treatment in binding of chromatin architecture factors, we performed ChIP-seq. We used chromatin from RPE1 cells treated with four different conditions: control (DMSO-treatment), doxorubicin treatment (200 nM and 340 nM) and ICRF193 treatment (5uM). Chromatin immunoprecipitation DNA-sequencing (ChIP-seq) for CTCF and RAD21.
创建时间：
2023-08-30
