Z-Score of CRESCENDO for Functional Residues.

The average Z-scores are shown for four categories of functional residues in the test-sets: catalytic activity, protein�Cprotein interactions, protein�Cnucleic acid interactions, and protein�Cligand interactions. The test-sets consist of 73 SCOP families, which is one third of SCOP families in ENZ (see Table 2).aTotal number of residue from test-sets (81,410).bResidue predicted by CRESCENDO.cActive-site residues (602).dProtein�Cprotein interaction sites (11,917).eProtein�Cnucleic acid interaction sites (194).fProtein�Cligand interaction sites (1,348).gRatio of Z-score at the active site residues compared with that of OLD-J.hP-value (right-tail) of the predicted residues.