Effect of four-week daily or less-frequent AT2220 administration on tissue glycogen levels in hP545L GAA Tg/KO mice.

Eight-week old male hP545L GAA Tg/KO mice were administered 100 mg/kg AT2220 ad libitum in drinking water for four weeks using the indicated regimens. Tissue glycogen levels were determined as described in “Materials and Methods”. The glycogen levels were normalized relative to baseline levels of untreated hP545L GAA Tg/KO (100%) and wild-type mice (0%). *p<0.05 compared to baseline; #p<0.05 compared to daily, as determined by t-test. Values represent the mean ± SEM for 7 mice per group.