Effects of nuclear-background variations and the presence or absence of B6-derived mtDNA with the G13997A mutation on the tumor-related phenotypes of mice.

* B6 mice and B6mtND613997 mice sharing the B6 nuclear genetic background received weekly urethane administration for 10 times (++). In contrast, F1 hybrids between B6 females and A/J males and F1 hybrids between B6mtND613997 females and A/J males received weekly administration of urethane for only twice (+) due to their higher susceptibility to urethane treatment than mice with B6 nuclear genetics background.** These results were reported previously (Hashizume et al., 2012).*** No mice developed lymphoma, since they were sacrificed to detect lung adenoma at 12 months of age.**** No mice developed lymphoma, since they died due to the Lkb1 mutation before lymphoma development.Effects of nuclear-background variations and the presence or absence of B6-derived mtDNA with the G13997A mutation on the tumor-related phenotypes of mice.