Supplementary Material for: Combined Renuvion and Endolift Therapy Suggests Enhanced Skin Tightening Compared to Monotherapy in Upper Arm Rejuvenation: A Case Report

Abstract Introduction: Skin laxity, a common aesthetic concern, drives demand for non-surgical solutions. Energy-based devices like Renuvion® (helium plasma/radiofrequency) and Endolift® (1470 nm diode laser) offer minimally invasive tightening, yet their combined efficacy remains underexplored. This study evaluates synergistic effects of Renuvion® and Endolift® through an intra-patient comparison. Case presentation: A 44-year-old female with moderate upper arm laxity underwent Renuvion® alone on the right arm and combined Renuvion® + Endolift® on the left. Endolift® (6 W, 50 ms ON/OFF pulses, 600 μm fiber) delivered 4000J-5000J per arm via subdermal scraping. Renuvion® followed one week later, using standard subdermal settings. Outcomes were assessed via laxity scoring, circumferential measurements, blinded practitioner evaluations and patient feedback at eight weeks. The combination arm demonstrated a higher reduction in circumference (34.3% vs. 28.8%) and superior practitioner ratings (3/3 vs. 2/3), indicating enhanced skin tightening. Blinded practitioners rated the left arm’s improvement as “marked” (score 3/3) vs. “moderate” (score 2/3) for the right. Patient satisfaction aligned with objective metrics, citing the left arm as “tighter” and “more contoured.” No adverse events occurred. Conclusion: Combining Renuvion® and Endolift® enhanced skin tightening compared to Renuvion® monotherapy, which may suggest synergistic subdermal remodeling. This dual-modality approach may optimize outcomes in fibrous anatomical regions, though larger controlled studies are warranted.