One-Pot Reaction To Obtain N,N′-Disubstituted Guanidines of Pyrazolo[4,3‑<i>e</i>][1,2,4]triazolo[1,5‑<i>c</i>]pyrimidine Scaffold as Human A₃ Adenosine Receptor Antagonists

In this paper we describe an extension SAR study of pyrazolo­[4,3-e]­[1,2,4]­triazolo­[1,5-c]­pyrimidine nucleus as A3AR antagonist. Our initial aim was to replace the phenylcarbamoyl moiety at the 5 position of PTP nucleus with a thiourea functionality to evaluate the contribution of new structural modification against the A3AR. The synthesized 12–25 were not characterized by the predicted side chain but by a 1,3-disubstituted guanidine and are shown to be interesting A3AR antagonists.