Canine diffuse large B-Cell lymphoma sequencing data. Canine diffuse large B-Cell lymphoma sequencing data

Diffuse large B-cell lymphoma (DLBCL) is a prevalent and aggressive cancer affecting both dogs and humans. While previous studies on canine DLBCL (cDLBCL) have significantly advanced veterinary oncology and highlighted the dog's potential as a comparative model, they have largely relied on whole-exome sequencing, restricting analysis to specific genomic regions. Our study aims to broaden the understanding of cDLBCL by conducting a comprehensive analysis of both coding and non-coding regions. We utilise whole-genome sequencing data from canine tumour/normal sample pairs to identify novel driver genes, potential biomarkers, and therapeutic targets, thereby enhancing our knowledge of cDLBCL and its comparative value in oncology research.