PRDX1: A Target Enabling Package

PRDXs are thiol-dependent peroxidases which catalyse the reduction of hydrogen peroxide, peroxynitrite and alkyl hydroperoxides. Peroxiredoxin-1 (PRDX1) is involved in modulating oxidative stress and exhibits cell specific expression in brain tissue. A pathological hallmark of neurodegenerative diseases includes progressive degenerative and neuronal death, which may be induced by an imbalance of reactive oxygen species. PRDX1 may therefore affect signalling pathways involved in neuroprotection and cell death by modulating oxidative stress. Several studies have shown a link between PRDX1 expression and Alzheimer’s disease. The aim of this project is to produce TEP reagents to help further understand the biology of PRDX1 in Alzheimer’s disease.