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PD-1-PD-L1 Axis Activation Suppresses CD8+ T Cells and Improves Nephritis [scRNA-seq, scTCR-seq]

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To dissect whether PD-1+CD8+ T cells are exhausted in lupus nephritis, scRNA-seq were performed to define the heterogeneous and pathologic subset. Splenic and kidney-infiltrating PD-1+CD8+ T cells were sorted for scRNA and scTCR sequencing.

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