Chromatin state transitions in the Drosophila intestinal lineage reveal principles of cell type specification [DamID]

To investigate the chromatin state into an adult stem cell lineage, we generate cell-type specific chromatin state maps in the adult Drosophila intestine and identify principal chromatin state transitions during lineage determination. we profiled the binding sites of five chromatin-associated proteins from which the previously described five major types of chromatin. Overall design: Comparative chromatin accessibility (ATAC-seq) as well as gene expression (RNA-seq) in Drosophila ISC/EB in control and H1 RNAi conditions