Crystal structure of human Cdk12/Cyclin K in complex with inhibitor SR-4835
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Crystal structure of human Cdk12/Cyclin K in complex with inhibitor SR-4835 Descriptor: Cyclin-K, Cyclin-dependent kinase 12, ~{N}-[[5,6-bis(chloranyl)-1~{H}-benzimidazol-2-yl]methyl]-9-(1-methylpyrazol-4-yl)-2-morpholin-4-yl-purin-6-amine Authors: Anand, K, Schmitz, M, Geyer, M. Deposit date: 2023-05-31 Release date: 2023-11-22 Last modified: 2024-10-16 Method: X-RAY DIFFRACTION (2.68 Å) Cite: The reversible inhibitor SR-4835 binds Cdk12/cyclin K in a noncanonical G-loop conformation. J.Biol.Chem., 300, 2023
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2023-05-31
