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Limiting cholesterol biosynthetic flux engages type I IFN signaling in a STING-dependent manner

ChEBI2015-12-10 更新2026-07-12 收录

免疫代谢

STING信号通路

数据链接：

https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-73942 数据链接链接失效反馈

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Limiting cholesterol biosynthetic flux engages type I IFN signaling in a STING-dependent manner

应用场景：

创建时间：

2015-12-10

免疫代谢

巨噬细胞炎症抑制

Macrophages undergo extensive metabolic rewiring upon activation and this serves many roles beyond the production of energy and anabolic building blocks. So-called immunometabolites that accumulate up

NIAID Data Ecosystem30

Additional file 2 of DNA methylation changes in metabolic and immune-regulatory pathways in blood and lymph node CD4 + T cells in response to SIV infections

病毒感染表观遗传学

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Additional file 2. Supplementary Table 1. Description of animals used for characterization of DNA methylation during SIV infection.

NIAID Data Ecosystem30

Genes in yeast two-hybrid screening.

宿主-病原体相互作用

免疫代谢

Intracellular bacterial pathogens exhibit heterogeneous replication rates within host macrophages, but the mechanisms by which they manipulate host factors for survival remain incompletely understood.

NIAID Data Ecosystem10

DataSheet_1_Low-density lipoprotein balances T cell metabolism and enhances response to anti-PD-1 blockade in a HCT116 spheroid model.zip

免疫代谢

PD-1联合治疗

IntroductionThe discovery of immune checkpoints and the development of their specific inhibitors was acclaimed as a major breakthrough in cancer therapy. However, only a limited patient cohort shows s

NIAID Data Ecosystem30

ADAR1 controls macrophage scavenging and lipid-buffering programs in metabolic tissues

免疫代谢

RNA功能分析

Data Table 1. List of RNA editing events per gene and pathway analysis. Data Table 2. List of DEGs for siADAR1, siADAR1-p150 and overlapping and pathway analysis for each comparison. Data Table 3. L

Zenodo2026-04-15 更新20

Limiting cholesterol biosynthetic flux engages type I IFN signaling in a STING-dependent manner

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