MyoD-Cre driven alterations in K-Ras and p53 lead to a mouse model with histological and molecular characteristics of human rhabdomyosarcoma

NIAID Data Ecosystem2026-03-13 收录

横纹肌肉瘤

基因工程小鼠

数据链接：

https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE195923 数据链接链接失效反馈

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资源简介：

This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

创建时间：

2022-02-23

低密度脂蛋白受体基因敲除小鼠

基因工程小鼠

代谢疾病

低密度脂蛋白受体（low density lipoprotein receptor，LDLR）基因家族中的一员。同于其能够与多种结构及功能各异的配体相互作用，不仅可以对血脂的动态平衡及纤溶功能的稳定进行调节。而且能参与多种生长因子、细胞激酶生物学效应的发挥.近来有研究表明LRP与动脉粥样硬化发生发展的多个环节密切相关并将其视为动脉粥样硬化性疾病又一新的危险因子。低密度脂蛋白受体相关蛋白受体敲除小鼠

中国科技资源共享网2026-07-13 更新200

Affymetrix SNP array data for pediatric rhabdomyosarcoma (RMS). Homo sapiens

横纹肌肉瘤

拷贝数变异分析

To elucidate the pathogenesis of rhabdomyosarcoma (RMS), particularly for different subgroups, we performed a SNP array-based copy number analysis of 54 RMS specimens from primary cases with ERMS (N =

NIAID Data Ecosystem60

Humanized C3 Mouse: A Novel Accelerated Model of C3 Glomerulopathy. Humanized C3 Mouse: A Novel Accelerated Model of C3 Glomerulopathy

C3肾小球病模型

基因工程小鼠

We developed a novel, rapidly-progressing, severe murine model of C3G by replacing the mouse C3 gene with the human C3 homologue using Velocigene® technology. We conducted functional, histological, mo

NIAID Data Ecosystem50

Data_Sheet_1_Different Response of Ptch Mutant and Ptch Wildtype Rhabdomyosarcoma Toward SMO and PI3K Inhibitors.pdf

横纹肌肉瘤

信号通路抑制

Rhabdomyosarcoma (RMS) is the most common pediatric soft tissue sarcoma with poor prognosis. RMS frequently show Hedgehog (HH) pathway activity, which is predominantly seen in the embryonal subtype (E

NIAID Data Ecosystem90

Chromatin states and transcription factor binding in SIX1 deficient Rhabdomyosarcoma cells. Chromatin states and transcription factor binding in SIX1 deficient Rhabdomyosarcoma cells

横纹肌肉瘤

转录因子结合分析

Genetic and shRNA-mediated inhibition of SIX1 expression in RMS cells induces myogenic differentiation and impedes RMS tumor growth. To elucidate the mechanism by which SIX1 loss activates a different

NIAID Data Ecosystem60

MyoD-Cre driven alterations in K-Ras and p53 lead to a mouse model with histological and molecular characteristics of human rhabdomyosarcoma

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