Lactobacillus rhamnosus Modulates the Neonatal Intestinal Microbiota Changes and Inflammatory Responses to Oral Inoculation with Bacteremia-producing Escherichia coli supplements

Our study aimed to determine the intestinal microbiota modifications following enteral acquisition of neonatal bacteremia-producing E. coli in newborn rats, and the effect of pretreatment with LGG on ameliorating the intestinal microbiota changes and intestinal inflammation produced by ExPEC infection in the neonatal period. We hypothesized that LGG significantly modulates the specific gut microbial populations changes and the inflammatory response elicited by the enteral introduction of septicemia-producing E. coli.