Chiral Semiconductor Nanoparticles for Site-Selective Photoinduced Cleavage of DNA Phosphodiester Bond
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https://figshare.com/articles/Chiral_Semiconductor_Nanoparticles_for_Site-Selective_Photoinduced_Cleavage_of_DNA_Phosphodiester_Bond/5954647
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资源简介：
chiral cysteine (Cys)-modified cadmium telluride (CdTe) nanoparticles (NPs) are shown to specifically recognize double-stranded DNA exceeding 90 base pairs and to selectively cut upon photonic excitation at the restriction site GAT¢ATC (¢ indicates the cleavage site). Notably, our results demonstrate that cleavage activity originates from photoinduced reactive oxygen species. This site-specific cleavage is attributed to the affinity between the Cys-modified CdTe and the specific DNA conformation proved by quantum chemically calculated interaction energies. Remarkably, the photoactive chiral NPs developed here as sequence-specific endonucleases performed well in living cells and in <i>vivo</i>.
提供机构：
figshare
创建时间：
2018-03-07
