Development of next-generation therapeutic antibodies using rapid mRNA immunization of humanized mice
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https://www.ncbi.nlm.nih.gov/sra/SRP402534
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资源简介：
We generated LNP-mRNAs encoding B.1.1.529 SARS-CoV-2 spike, or single transmembrane protein CD22, or GPCR GPRC5D, respectively. Those LNP-mRNAs were intramuscularly administered in a human IgG and IgK knock-in mouse. Single cell VDJ-seq unveiled the sequences of human monoclonal antibodies targeting those target antigens. Overall design: Three sets of B cells were isolated and processed from the spleen, lymph nodes, bone marrows, or peripheral blood of immunized mouse. Those B cells were subjected to scVDJ-seq, respectively.
创建时间：
2023-10-01
