Transcriptional changes in response to OXA-23 overexpression in Acinetobacter baumannii ATCC 17978

Purpose: The goal of this study was to elucidate the collateral effects associated with OXA-23 overexpression on the Acinetobacter baumannii global transcriptome. Results: Besides the 99.73-fold increase in blaOXA-23 transcript upon IPTG induction, no other transcripts showed more than a 2-fold change compared to the wildtype control. This suggests that OXA-23 over expression to levels similarly observed in multi drug resistant A. baumannii clinical isolates does not effect the transcriptome. Overall design: Global mRNA profiles of A. baumannii ATCC 17978 wildtype and IPTG-induced OXA-23 overexpression