Analytic framework for Section 2.1.
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Two SNP-pairs (where each wi, vj denotes the probability of the respective genotype combination) and four penetrance levels (pkℓ, k, ℓ ∈ {0, 1}). Certain relationships among the four penetrance parameters, e.g., Eq (4), can make it impossible for us to determine an appropriate disease model for the underlying pair based on the case-control ratios.
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2019-03-27
