Willingness of seasonal influenza vaccination and associated factors among pregnant women in Shanghai

Objective　To analyze the willingness of influenza vaccination and related factors among pregnant women in Shanghai. Methods　An online questionnaire survey was conducted among pregnant women who registered in maternal and child health hospitals in 16 districts of Shanghai. The basic information, health status during pregnancy, attitude towards influenza vaccination, and knowledge of influenza and influenza vaccine were collected and multivariate logistic regression analysis were used to analyze the willingness and related factors of influenza vaccination during pregnancy. Results　A total of 3 219 valid questionnaires were received., of which 10.90% of pregnant women were willing to receive influenza vaccination during pregnancy, 57.50% were unwilling to receive vaccination, and 31.59% were uncertain. Among those who were willing to receive the vaccine, 82.91% would take the initiative to know the relevant information of the influenza vaccine, 87.18% understood how the flu spreads, and 32.09% believed that pregnant women could receive the influenza vaccination at any stage of pregnancy; while among those who were unwilling or uncertain, the proportions of the above three questions were 47.06%, 83.95% and 17.80%, respectively. Among pregnant women who were unwilling or uncertain, the main reason for their vaccine hesitation was the concern about the safety of the vaccine for pregnant women and fetuses during pregnancy. Multivariate logistic regression analysis showed that pregnant women with a higher education (OR=3.278, 95%CI：1.678~6.406，P=0.001), second trimester (OR=1.542, 95%CI: 1.159~2.054, P=0.003), third pregnancy (OR=2.318，95%CI：1.008~5.331, P=0.048), and previous influenza vaccination (OR=1.552, 95%CI: 1.119–2.152, P=0.008) were more willing to receive influenza vaccination than others. Conclusion　Pregnant women in Shanghai were relatively less willing to receive influenza vaccination during pregnancy, and the main related factor was the concern about vaccine safety.