Integrated Proteomic Characterization of Maternal Blood, Umbilical Cord Blood and Placenta Tissue of Gestational Diabetes Mellitus Patients

In this retrospective study, a diverse set of biological specimens was assembled, consisting of maternal blood, umbilical cord blood, and placenta tissue, from a cohort of 22 mothers with gestational diabetes mellitus and a matched group of 19 healthy mothers. Integrated proteomic characterization of these samples were performed, and functional enrichments based on GO and KEGG database, as well as Gene Set Enrichment Analysis were used to elucidate the pathways involved in the pathophysiology of gestational diabetes mellitus. Moreover, a weighted protein co-expression network was constructed to analysis the correlation of expression modules with clinical traits.