NHLBI TOPMed: Children's Health Study (CHS) Effects of Air Pollution on the Development of Obesity in Children (Meta-AIR)

The Effects of Air Pollution on the Development of Obesity in Children (Meta-AIR) study was proposed to study a subset of the Children's Health Study (CHS) participants representing the extremes of long-term traffic-related air pollution exposure occurring in Southern California CHS communities. The primary aim of the Meta-AIR study was to investigate whether lifetime exposure to air pollution increases risk for obesity and metabolic dysfunction at 17-18 years of age. A total of 56 Hispanic White participants (16 asthma cases and 40 controls) were included in the TOPMed project.]]>
TOPMed Whole Genome Sequencing Methods: Freeze 8TOPMed Whole Genome Sequencing Methods: Freeze 9A total of 200 subjects were enrolled from the CHS cohort. They are overweight or obese participants based on body mass index (BMI) percentiles at the 2011-12 school year annual assessment. To increase power, we selected subjects using sampling probabilities designed to maximize exposure contrasts to traffic-related air pollutants.]]>
Enrollment Years Meta-AIR: October 2013 to present]]>