SSEA-4 labels a subset of poor prognosis-associated osteosarcoma-initiating cells that respond to differentiation induction. Homo sapiens

Osteosarcoma is thought of arising from the malignant transformation of osteogenic progenitors. The stage-specific embryonic antigen-4 (SSEA-4) labels a subset of TICs specially present in the high-risk subgroup. Overall design: SSEA-4+ AND SSEA-4-