Role of cohesin in cancer development. Homo sapiens
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资源简介：
The aim of this project is to understand the role of cohesin in both genome instability and colorectal cancer development
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创建时间：
2018-04-23
相关数据集
Cohesion is established during DNA replication utilising chromosome associated cohesin rings as well as those loaded de novo onto nascent DNAs
Cohesin is established by two parallel pathways during DNA replication. Chromosome associated cohesin is converted to cohesive structures and this depends on four protein associated with the replisome
NIAID Data Ecosystem50
PDS5A and PDS5B differentially affect gene expression without altering cohesin localization across the genome [RNA-seq]. PDS5A and PDS5B differentially affect gene expression without altering cohesin localization across the genome [RNA-seq]
Purpose: Cohesin is an important structural regulator of the genome. Whether cohesin HEAT repeat accessory proteins PDS5A and PDS5B differentially contribute to cohesin function remains unclear. The p
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The profiling of gut microbiota during colorectal cancer development
The imbalance of intestinal flora may promote the occurrence and development of colorectal cancer, changes of the intestinal flora during the development of colorectal cancer and the mechanism that pr
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Neu5Gc intake increases the expression of colorectal cancer-related genes in the APCMin+ mouse
Clinical cohort data suggest that high consumption of red meat containing N-glycolylneuraminic acid (Neu5Gc) may increase colorectal prevalence, therefore, we investigated the effect of high Neu5Gc in
NIAID Data Ecosystem30
Analysis by Mnase-seq of the chromatin structure of wild type cells and cells in which chromatin structure is perturbed (histone H4 depletion) in the presence or absence of the kleisin subunit of cohesin, Scc1. Analysis by Mnase-seq of the chromatin structure of wild type cells and cells in which chromatin structure is perturbed (histone H4 depletion) in the presence or absence of the kleisin subunit of cohesin, Scc1
The main objective of this study is to determine how cohesin influences chromatin structure and chromatin assembly during DNA replication Overall design: Chromatin structure has been determined by MNa
NIAID Data Ecosystem20
