TANK is ubiquitinated within TANK:K63polyUb-TRAF3:TICAM1:TLR3:viral dsRNA

Upon stimulation by pathogen-associated inflammatory signals TANK associates with TRAF3 which may result in K63-linked ubiquitination of TANK (Gatot JC et al. 2007). How the ubiquitination of TANK contributes to the activation of TBK1 and/or IKKepsilon remains unclear.

在病原体相关炎症信号的刺激下，TANK蛋白与TRAF3蛋白相互作用，可能导致TANK蛋白发生K63链连接的泛素化（Gatot JC 等，2007年）。TANK蛋白泛素化如何参与TBK1和/或IKKepsilon的激活过程尚不明确。