Cancer/testis Antigen-Plac1 Promotes Invasion and Metastasis of Breast Cancer. Cancer/testis Antigen-Plac1 Promotes Invasion and Metastasis of Breast Cancer

PLAC1, cancer-testis antigen, is a crucial element in tumorigenesis and development programs for many cancers. Overexpression of PLAC1 promoted invasion and metastasis of breast cancer cells in vitro and in vivo. Co-immunoprecipitation and immunofluorescence cell staining assays be used revealed that PLAC1 physically interact with Furin to degrade Notch1 and generate NICD (Notch1 intracellar domain) and further inhibit Pten, which is also supported by the microarray analysis. Overall design: Examination of gene expression pattern in 2 cell types. ---------------------------- KangChen Bio-tech