Single-cell transcriptomic analysis of mouse CA1 inhibitory neurons

We studied the transcriptomes of mouse CA1 inhibitory cells. Novel clustering methods identified all 23 previously described CA1 inhibitory types, while also suggesting 6 new inhibitory classes. Latent-factor analysis revealed a common continuum of expression of many genes within and between classes, which we hypothesized correlates with a continuum from faster-spiking cells that proximally target pyramidal cells, to slower active cells targeting pyramidal distal dendrites or interneurons. Overall design: 6971 single cells isolated from the mouse cortex CA1 region