Complex I form respirasome closed state bound by proguanil (SC-ProgC)

Complex I form respirasome closed state bound by proguanil (SC-ProgC) Descriptor: (4S,7R)-4-hydroxy-N,N,N-trimethyl-7-(octadecanoyloxy)-4,10-dioxo-3,5,9-trioxa-4lambda~5~-phosphaheptacosan-1-aminium, (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL, 1,2-Distearoyl-sn-glycerophosphoethanolamine, ... Authors: Teng, F, He, Z.X, Hu, Y.Q, Xu, C.Y, Guo, R.Y, Zhou, L. Deposit date: 2024-06-15 Release date: 2025-11-19 Last modified: 2026-02-04 Method: ELECTRON MICROSCOPY (3.14 Å) Cite: Hydrophilic metformin and hydrophobic biguanides inhibit mitochondrial complex I by distinct mechanisms. Nat.Struct.Mol.Biol., 33, 2026