Vascular smooth muscle cell senescence instigates thoracic aortic aneurysm

In this study, we identified various cell clusters in human normal/sporadic TAA ascending aorta samples by single-cell RNA sequencing (scRNA-seq), and discovered the senescent vascular smooth muscle cells (VSMCs) significantly increased in TAA samples. Then we explored the molecular basis of TAA progression, and recognized the key regulators and pathways involved in the TAA progression regulation. Single cell RNA-Seq of human normal/sporadic thoracic aortic aneurysm (TAA) ascending aorta samples