drug_induced_liver_injury

## Dataset Details ### Dataset Description Drug-induced liver injury (DILI) is fatal liver disease caused by drugs and it has been the single most frequent cause of safety-related drug marketing withdrawals for the past 50 years (e.g. iproniazid, ticrynafen, benoxaprofen). This dataset is aggregated from U.S. FDA 2019s National Center for Toxicological Research. - **Curated by:** - **License:** CC BY 4.0 ### Dataset Sources - [corresponding publication](https://doi.org/10.1021/acs.jcim.5b00238) - [Data source](https://tdcommons.ai/single_pred_tasks/tox/#dili-drug-induced-liver-injury) ## Citation **BibTeX:** ```bibtex @article{Xu2015, doi = {10.1021/acs.jcim.5b00238}, url = {https://doi.org/10.1021/acs.jcim.5b00238}, year = {2015}, month = oct, publisher = {American Chemical Society (ACS)}, volume = {55}, number = {10}, pages = {2085-2093}, author = {Youjun Xu and Ziwei Dai and Fangjin Chen and Shuaishi Gao and Jianfeng Pei and Luhua Lai}, title = {Deep Learning for Drug-Induced Liver Injury}, journal = {Journal of Chemical Information and Modeling} ```数据集详情 ## 数据集描述 药物性肝损伤（Drug-induced liver injury, DILI）是由药物引发的致命性肝脏疾病，在过去50年中一直是导致药物因安全性问题被撤市的最常见单一诱因（例如异丙烟肼（iproniazid）、替尼酸（ticrynafen）、苯恶洛芬（benoxaprofen））。本数据集整合自美国食品药品监督管理局（U.S. FDA）2019年的国家毒理学研究中心（National Center for Toxicological Research）相关数据。 - **整理方：** - **许可协议：** CC BY 4.0 ## 数据集来源 - [相关研究论文](https://doi.org/10.1021/acs.jcim.5b00238) - [数据来源](https://tdcommons.ai/single_pred_tasks/tox/#dili-drug-induced-liver-injury) ## 引用信息 ### BibTeX 引用格式： bibtex @article{Xu2015, doi = {10.1021/acs.jcim.5b00238}, url = {https://doi.org/10.1021/acs.jcim.5b00238}, year = {2015}, month = oct, publisher = {美国化学会（ACS）}, volume = {55}, number = {10}, pages = {2085-2093}, author = {徐友俊、戴子玮、陈方进、高帅石、裴健峰、赖良华}, title = {深度学习用于药物性肝损伤}, journal = {化学信息与建模杂志（Journal of Chemical Information and Modeling)} }

搜集汇总

背景与挑战

背景概述

该数据集聚焦于药物性肝损伤（DILI），这是一种由药物引发的致命性肝脏疾病，常导致药物因安全问题撤市。数据来源于美国FDA国家毒理学研究中心2019年的汇总，采用CC BY 4.0许可协议。