drug_induced_liver_injury

## Dataset Details

### Dataset Description

Drug-induced liver injury (DILI) is fatal liver disease caused by drugs
and it has been the single most frequent cause of safety-related drug marketing
withdrawals for the past 50 years (e.g. iproniazid, ticrynafen, benoxaprofen).
This dataset is aggregated from U.S. FDA 2019s National Center for Toxicological
Research.

- **Curated by:**
- **License:** CC BY 4.0

### Dataset Sources

- [corresponding publication](https://doi.org/10.1021/acs.jcim.5b00238)
- [Data source](https://tdcommons.ai/single_pred_tasks/tox/#dili-drug-induced-liver-injury)

## Citation

**BibTeX:**

```bibtex
@article{Xu2015,
doi = {10.1021/acs.jcim.5b00238},
url = {https://doi.org/10.1021/acs.jcim.5b00238},
year = {2015},
month = oct,
publisher = {American Chemical Society (ACS)},
volume = {55},
number = {10},
pages = {2085-2093},
author = {Youjun Xu and Ziwei Dai and Fangjin Chen
and Shuaishi Gao and Jianfeng Pei and Luhua Lai},
title = {Deep Learning for Drug-Induced Liver Injury},
journal = {Journal of Chemical Information and Modeling}
```

数据集详情

## 数据集描述
药物性肝损伤（Drug-induced liver injury, DILI）是由药物引发的致命性肝脏疾病，在过去50年中一直是导致药物因安全性问题被撤市的最常见单一诱因（例如异丙烟肼（iproniazid）、替尼酸（ticrynafen）、苯恶洛芬（benoxaprofen））。本数据集整合自美国食品药品监督管理局（U.S. FDA）2019年的国家毒理学研究中心（National Center for Toxicological Research）相关数据。
- **整理方：**
- **许可协议：** CC BY 4.0

## 数据集来源
- [相关研究论文](https://doi.org/10.1021/acs.jcim.5b00238)
- [数据来源](https://tdcommons.ai/single_pred_tasks/tox/#dili-drug-induced-liver-injury)

## 引用信息

### BibTeX 引用格式：
bibtex
@article{Xu2015,
doi = {10.1021/acs.jcim.5b00238},
url = {https://doi.org/10.1021/acs.jcim.5b00238},
year = {2015},
month = oct,
publisher = {美国化学会（ACS）},
volume = {55},
number = {10},
pages = {2085-2093},
author = {徐友俊、戴子玮、陈方进、高帅石、裴健峰、赖良华},
title = {深度学习用于药物性肝损伤},
journal = {化学信息与建模杂志（Journal of Chemical Information and Modeling)}
}

搜集汇总

背景与挑战

背景概述

该数据集聚焦于药物性肝损伤（DILI），这是一种由药物引发的致命性肝脏疾病，常导致药物因安全问题撤市。数据来源于美国FDA国家毒理学研究中心2019年的汇总，采用CC BY 4.0许可协议。