Empagliflozin Attenuates Obesity-Related Kidney Dysfunction

To further elucidate the mechanism by which EMPA protects OKD, we analyzed the mouse kidney transcriptome by RNA-Seq and found 102 DEGs shared in three groups. GO and KEGG enrichment showed that these DEGs were mainly enriched in cytokines, chemokines, and tumor necrosis factor signaling pathways, all of which were association with inflammation process. We discovered that HFD affects inflammatory processes; EMPA can attenuate these processes.