Association between rt-PA and clinical outcomes in the full cohort.

OR: odds ratio, CI: confidence interval, ICH: intracranial hemorrhage. Neurological improvement was defined as a ≥4 point decrease in the NIHSS score during hospitalization or a NIHSS score of 0 at discharge. Good functional outcome was defined as an mRS score of 0–2 at discharge. Multivariable logistic model for neurological improvement, good functional outcome, and in-hospital mortality included age, sex, hypertension, dyslipidemia, diabetes, atrial fibrillation, smoking, drinking, chronic kidney disease, pre-stroke independency, previous stroke, previous ischemic heart disease, pre-antithrombotic therapy, cardioembolic stroke, admission within 2 h of onset, and NIHSS on admission. Multivariable logistic model for ICH, symptomatic ICH, and gastrointestinal bleeding included age, sex, systolic blood pressure, diabetes, chronic kidney disease, and NIHSS on admission.Association between rt-PA and clinical outcomes in the full cohort.