Model-predicted potential regulation targets to impair high CO2-induced closure.

If a knockout of a signaling element impairs high CO2-induced closure, the model predicts the knockout will perturb one of these nodes. The first 3 rows are categorized based on the network location of the node, i.e., which component it is in. The last row is an extension where we hypothesize that perturbations causing hyposensitivity in the model could also be considered as having the potential to impair closure. Bold font indicates an example of 9 prioritized targets for BIG1, which are downstream of bicarbonate and whose perturbation can also cause reduced SLAC1 activity, as observed in the big1 mutant.