Crystal structure of PDE6D in complex with the inhibitor rac-2
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Crystal structure of PDE6D in complex with the inhibitor rac-2 Descriptor: 1-benzyl-2-(4-{[(2R)-2-(2-phenyl-1H-benzimidazol-1-yl)pent-4-en-1-yl]oxy}phenyl)-1H-benzimidazole, Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta Authors: Gunther, Z, Papke, B, Ismail, S, Vartak, N, Chandra, A, Hoffmann, M, Hahn, S, Triola, G, Wittinghofer, A, Bastiaens, P, Waldmann, H. Deposit date: 2013-03-25 Release date: 2013-05-22 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (1.75 Å) Cite: Small molecule inhibition of the KRAS PDEd interaction impairs oncogenic KRAS signalling Nature, 497, 2013
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2013-03-25
