HIV Infection in Humanized Microglial Mice Disrupts Feeding Behavior and Circadian Rhythms with Cortical Neuroinflammation

This dataset contains lists of significant differentially expressed genes (DEGs) identified in the brain tissue of humanized NOG-hIL34 mice. The data compares HIV-1 infected mice against uninfected control mice across two distinct brain regions: the frontal cortex and the hippocampus. Data profiles include both human (engrafted) and murine (host) transcriptomic responses to evaluate species-specific cellular changes during HIV infection. Data structure Human DEGs in the frontal cortex (Control vs. HIV): Located in Supplementary Table_S3 Human DEGs in the hippocampus (Control vs HIV: Located in Supplementary Table_S4 Mouse DEGs in the frontal cortex (Control vs. HIV): Located in Supplementary Table_S5 Mouse DEGs in the hippocampus (Control vs HIV: Located in Supplementary Table_S6 Statistical Significance: DEGs were filtered using a significance threshold of adjusted p-value (corrected significant difference value) < 0.05 and |log2 fold change| > 1.