Minor intron splicing efficiency increases with the development of lethal prostate cancer
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https://www.omicsdi.org/dataset/ega/EGAS00001005546
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We sought to determine the effect of a minor spliceosome inhibition by U6atac snRNA depletion in prostate cancer. We performed siRNA-mediated knock-down (96h) of the minor spliceosome snRNA U6atac in androgen-sensitive LNCaP cells, androgen-insensitive C4-2 and 22Rv1 cells and in patient derived neuroendocrine organoids (PM154). We compared global transcriptional alterations and lineage dependency using RNA-seq and scRNAseq.EGA study EGAS00001005546
创建时间：
2022-11-16
