Dynamic Modeling of Cellular Populations within iBioSim

As the complexity of synthetic genetic circuits increases,
modeling
is becoming a necessary first step to inform subsequent experimental
efforts. In recent years, the design automation community has developed
a wealth of computational tools for assisting experimentalists in
designing and analyzing new genetic circuits at several scales. However,
existing software primarily caters to either the DNA- or single-cell
level, with little support for the multicellular level. To address
this need, the iBioSim software package has been enhanced to provide
support for modeling, simulating, and visualizing dynamic cellular
populations in a two-dimensional space. This capacity is fully integrated
into the software, capitalizing on iBioSim’s strengths in modeling,
simulating, and analyzing single-celled systems.