Neutrophils, Lymphocyte and Monocyte counts in blood.
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Values were normalized to Hctc (109/l at a Hctc of 0.4). Baseline values were obtained prior to administration of compounds. Abbreviations: CPB, cardiopulmonary bypass; baseline, 15 min after injection of the experimental compound of the vehicle; start ECC, 15 min before extracorporeal circulation; end ECC, 15 min after extracorporeal circulation; 24 h, scarification at 24 h later the end of the extracorporeal circulation. a- p<0.05 vs Baseline, t-test; b- p<0.05 untreated CPB 24 h vs all other CPB untreated groups, One-Way ANOVA, Bonferroni test; c-p<0.05 vs Sham FTY720 baseline, One-Way ANOVA on ranks, Dunn's Method (SigmaStat); d- p<0.05 vs Sham FTY720 baseline, One-Way ANOVA, Bonferroni test; e- p<0.05 vs CPB FTY720 baseline, One-Way ANOVA, Bonferroni test; f- p<0.05, vs Sham SEW2871 baseline, One-Way ANOVA, Bonferroni test; g- p<0.05 CPB SEW2871 24 h vs all other CPB2871 groups, One-Way ANOVA, Bonferroni test.
