Digging into the transcriptomic profile of mesenchymal stem cells diagnosed with 21 trisomy

The molecular mechanism involved in Down's syndrome (DS) is more complex than previously thought. This study provides a comprehensive overview of DS through the whole transcriptomic profile obteined by NGS of MSCs isolated from CV derived from women carrying foetuses with diagnosed DS in comparison to their euploid counterparts (CV), revealing the existence of a wide range of molecular signatures involved in the regulation of cell cycle, proliferation and phenotype. Overall design: Total RNA was obtained from Mesenchymal stem cells (MSCs) isolated from chorionic Villi (CV) and chorionic Villi with down's syndrome (DS-CV). CV was used as controls.