Cryo-EM structure of LRRK2 bound to type I inhibitor LRRK2-IN-1
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Cryo-EM structure of LRRK2 bound to type I inhibitor LRRK2-IN-1 Descriptor: 2-[(2-methoxy-4-{[4-(4-methylpiperazin-1-yl)piperidin-1-yl]carbonyl}phenyl)amino]-5,11-dimethyl-5,11-dihydro-6H-pyrimido[4,5-b][1,4]benzodiazepin-6-one, GUANOSINE-5'-DIPHOSPHATE, Leucine-rich repeat serine/threonine-protein kinase 2 Authors: Zhu, H, Sun, J. Deposit date: 2022-12-29 Release date: 2024-01-17 Last modified: 2025-05-14 Method: ELECTRON MICROSCOPY (3.52 Å) Cite: Pharmacology of LRRK2 with type I and II kinase inhibitors revealed by cryo-EM. Cell Discov, 10, 2024
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2022-12-29
