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IC<sub>50</sub> values and standard errors resulting from the competitive binding assay performed in four replicates with wt-ER<sub>α</sub><sup>LBD</sup> (column 2), M421F- ER<sub>α</sub><sup>LBD</sup> (column 3) and M421I- ER<sub>α</sub><sup>LBD</sup> (column 4) and selected compounds (ligands, co

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The M421F-ERαLBD shows lower IC50, compared to wt-ERαLBD, for four compounds (17β-estradiol, 17α-ethinylestradiol, bisphenol-A and 4-nonylphenol) out of six. The M421I-ERαLBD has higher IC50, compared to wt-ERαLBD, for all the tested compounds.

创建时间:
2014-07-30
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