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BRCA mutational status shapes the stromal microenvironment of pancreatic cancer linking CLU+ CAF expression with HSF1 signaling

NIAID Data Ecosystem2026-03-14 收录

胰腺癌微环境

BRCA突变功能

数据链接：

https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE200617 数据链接链接失效反馈

官方服务：

资源简介：

This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

应用场景：

创建时间：

2023-01-10

胰腺癌微环境

环状RNA表达

Although how CAFs impact the tumor epithelium is being progressively unveiled, transcriptional processes of lineage plasticity in fibroblasts govern the acquisition and transition of the CAF phenotype

NIAID Data Ecosystem60

Additional file 2 of Immune checkpoint inhibition for pancreatic ductal adenocarcinoma: limitations and prospects: a systematic review

肿瘤免疫治疗

胰腺癌微环境

Additional file 1. The mechanism of endothelial cell entry into the pancreatic cancer microenvironment and its immunosuppressive effect.

NIAID Data Ecosystem50

LIFR antagonism reverses epithelial pro-CAF programs in pancreatic ductal adenocarcinoma

胰腺癌微环境

FGFR靶向治疗

In PDAC cancer cells, MIAPaCa-2 cells, LIF induced a coordinated transcriptional network encompassing inflammatory mediators, paracrine fibroblast-activating signals and ECM/mechanotransductive module

NIAID Data Ecosystem20

Gene profiling of the antitumor effects of Cxcl13-positive pancreatic stellate cells in an allogeneic subcutaneous transplantation model.

胰腺癌微环境

转录组分析

Pancreatic stellate cells are a kind of fibroblasts present in the pancreas and are the cells of origin of cancer-associated fibroblasts. In our previous study, we demonstrated the presence of Cxcl13-

NIAID Data Ecosystem50

Disease associated fibroblasts from various pancreatic disorders exhibit subtype specific genetic profile [RNA]

胰腺癌微环境

成纤维细胞异质性

Currently it is unknown whether activation of recruited or resident pancreatic fibroblasts, including pancreatic stellate cells activation, create a common “fibroblast-activated phenotype” indistingui

NIAID Data Ecosystem30

BRCA mutational status shapes the stromal microenvironment of pancreatic cancer linking CLU+ CAF expression with HSF1 signaling

资源简介：

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