Formation mechanism of thermosensitive chitosan hydrogels containing uridine 5’-monophosphate disodium salt – data set

The gelation mechanisms of two types of thermosensitive chitosan hydrogels containing a salt of pyrimidine nucleotide – uridine 5’-monophosphate disodium salt (UMP), as a cross-linking agent were developed. These systems were prepared from chitosan lactate and chitosan chloride solutions. They were characterised by the ability to transition from sol to gel at both low and high temperatures. The formation mechanisms of the above hydrogels were proposed based on the analysis of FTIR spectra of the chitosan systems at 4°C and 37°C without and with the addition of uridine 5’-monophosphate disodium salt. It has been demonstrated that the sol-gel transition of chitosan colloids is a complex, multi-step process resulting from the coexistence of multiple interactions (electrostatic interactions, hydrogen bonds and hydrophobic interactions) that determine the final properties of the hydrogels. This research was funded by the Young Scientists Fund at the Faculty of Process and Environmental Engineering at the Lodz University of Technology, Poland [grant number: 501/10-34-2-7058], and in part by the National Science Centre, Poland, within a “MINIATURA 8” grant, [grant number: 2024/08/X/ST8/01313].