RNA-seq analysis of the induced membrane following polymethyl methacrylate-induced membrane formation

Diabetic Foot Ulceration(DFU) is a prevalent complication among diabetic patients, significantly impairing their quality of life. Polymethyl methacrylate-induced membrane therapy has gained increasing attention as a specialized healing tissue closely linked to bone regeneration. This study aims to explore the impact of Polymethyl methacrylate-induced membrane therapy on the transcriptome of DFU tissues. We utilized high-throughput RNA-seq to identify genes and signaling pathways among DFU tissue before PMMA treatment (Group A), the induced membrane (Group B), and DFU tissue after PMMA treatment (Group C).