Summary of unreported independent GWAS signals of severe obesity traits in the discovery and replication cohorts. Independent signals were defined as lead variants having met a genome-wide significant <i>P</i> value (<i>P</i> < 5 × 10⁻⁸) in our discovery cohort and a Bonferroni adjusted significance (<i>P = </i>0.005) in the replication cohort across any strata (all, men, or women) had a linkage disequilibrium (LD) <i>r</i>² < 0.6 with other variants and were defined as those independent from each other at <i>r</i> ^<i>2</i>< 0.1 inside a subset of independent significant variants. Genes were annotated based on ±250kb of the lead variant and/ or closest gene present.

Summary of unreported independent GWAS signals of severe obesity traits in the discovery and replication cohorts. Independent signals were defined as lead variants having met a genome-wide significant P value (P < 5 × 10−8) in our discovery cohort and a Bonferroni adjusted significance (P = 0.005) in the replication cohort across any strata (all, men, or women) had a linkage disequilibrium (LD) r2 < 0.6 with other variants and were defined as those independent from each other at r 2 < 0.1 inside a subset of independent significant variants. Genes were annotated based on ±250kb of the lead variant and/ or closest gene present.