Genome wide anaylsis of transcriptome modifications in male mice exposed to tributyltin during development

Purpose: To identify alterations induced by developmental exposure to tributyltin at different stages of life Methods: Dams were treated with tributyltin during gestation and lactation in drinking water and pups were euthanized at different ages Results: We identified a number of changes in transcriptomic activity in 5 month, and ten month old pups after tributyltin exposure. Male animals exposed to tributyltin also developed fatty liver 5 months of age and adenomas of the liver at ten months of age. Overall design: Liver was isolated from animals exposed to tributyltin during development at 5 months and 10 months. At 10 months of age adenomas were also collected.